The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2016

Filed:

May. 30, 2014
Applicant:

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Motoichi Kurisawa, Singapore, SG;

Shengyong Ng, Singapore, SG;

Joo Eun Chung, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 9/16 (2006.01); A61K 9/10 (2006.01); A61K 31/353 (2006.01); A61K 31/7048 (2006.01); A61K 31/728 (2006.01); A61K 47/48 (2006.01); A61K 31/4706 (2006.01); A61K 38/48 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1617 (2013.01); A61K 9/10 (2013.01); A61K 9/1652 (2013.01); A61K 31/353 (2013.01); A61K 31/4706 (2013.01); A61K 31/7048 (2013.01); A61K 31/728 (2013.01); A61K 38/482 (2013.01); A61K 47/4823 (2013.01); C07K 16/18 (2013.01);
Abstract

There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.


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