The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Sep. 30, 2011
Giuseppe DE Rosa, Naples, IT;
Michele Caraglia, Ariano Irpino, IT;
Pierfrancesco Tassone, Catanzaro, IT;
Maria Immacolata LA Rotonda, Naples, IT;
Alberto Abbruzzese Saccardi, Naples, IT;
Giuseppina Salzano, Casavatore, IT;
Monica Marra, Naples, IT;
Carlo Leonetti, Rome, IT;
Giuseppe De Rosa, Naples, IT;
Michele Caraglia, Ariano Irpino, IT;
Pierfrancesco Tassone, Catanzaro, IT;
Maria Immacolata La Rotonda, Naples, IT;
Alberto Abbruzzese Saccardi, Naples, IT;
Giuseppina Salzano, Casavatore, IT;
Monica Marra, Naples, IT;
Carlo Leonetti, Rome, IT;
Istituti Fisioterapici Ospitalieri, Rome, IT;
Abstract
The present invention describe nanocomplexes also called auto-assembling nanoparticles comprising biphosphonates, lipid nanovectors and inorganic nanovectors. In particular the invention describes zoledronic acid complexed with calcium phosphate base nanoparticles; said particles in their turn mixed with lipidic particles e.g. liposomes. Said nanocomplexes are useful, and showed to be efficient in vivo, as pharmaceutical formulations of biphosphonates for the treatment or prevention of tumor growth and/or metastasis. Tumors can be solids and/or haematological such as prostate, lung, head/neck, colon, liver, breast, pancreas, kidneys, bladder, male and female urogenital tract, bones, multiple myeloma, primitive and secondary tumors of the central nervous system and lymphomas.