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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9222136 B1

PDFFull Text
Date of Patent:
Dec. 29, 2015

Filed:

Dec. 05, 2008

Alternative splice variant patterns of human telomerase reverse transcriptase (htert) in thyroid tumors to distinguish benign from malignant

Applicants:

Martha Allen Zeiger, Baltimore, MD (US);

Jeanne Kowalski, Baltimore, MD (US);

Christopher Umbricht, Baltimore, MD (US);

Yongchun Wang, Baltimore, MD (US);

Inventors:

Martha Allen Zeiger, Baltimore, MD (US);

Jeanne Kowalski, Baltimore, MD (US);

Christopher Umbricht, Baltimore, MD (US);

Yongchun Wang, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:

Johns Hopkins Technology Transfer

Primary Examiner:

Michele K Joike

Assistant Examiner:

Mindy G Brown

Int. Cl.
CPC ...
C12Q 1/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01);
Abstract

This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the β sequence and the amount of TERT mRNA in the sample which comprises the β sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the β sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the β sequence indicates that the tumor is not malignant.

Find Patent Forward Citations

Zeiger, Martha. (2015). Alternative splice variant patterns of human telomerase reverse transcriptase (htert) in thyroid tumors to distinguish benign from malignant (U.S. Patent No. 9222136). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9222136

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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