The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
Dec. 23, 2008
Elmar Kraus, Bad Vilbel, DE;
Christoph Bruecher, Eschborn, DE;
Benjamin Daelken, Frankfurt am Main, DE;
Matthias Germer, Langen, DE;
Steffen Zeng, Muenster, DE;
Frank Osterroth, Dietzenbach, DE;
Christoph Uherek, Seligenstadt, DE;
Silke Aigner, Frankenthal, DE;
Gregor Schulz, Umkirch, DE;
Elmar Kraus, Bad Vilbel, DE;
Christoph Bruecher, Eschborn, DE;
Benjamin Daelken, Frankfurt am Main, DE;
Matthias Germer, Langen, DE;
Steffen Zeng, Muenster, DE;
Frank Osterroth, Dietzenbach, DE;
Christoph Uherek, Seligenstadt, DE;
Silke Aigner, Frankenthal, DE;
Gregor Schulz, Umkirch, DE;
BIOTEST AG, Dreieich, DE;
Abstract
Disclosed is a human murine chimeric antibody targeting CD138 which substantially retains the antigen binding region of its murine counterpart. The engineered antibody displays improved binding affinities to the antigen and/or more homogenous binding to target cells relative to its murine counterpart. A constant region of the immunoglobulin heavy chain is preferably an IgG4 isotype constant region.