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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9221893 B1

PDFFull Text
Date of Patent:
Dec. 29, 2015

Filed:

Dec. 05, 2011

Hyaluronic acid-protein conjugates and method for preparing same

Applicants:

Sei Kwang Hahn, Pohang-si, KR;

Jeong A. Yang, Pohang-si, KR;

Seung Kyu Yoon, Seocho-gu, KR;

Won Hee Hur, Seocho-gu, KR;

Ki Tae Park, Jeonju-si, KR;

Hye Min Kim, Pohang-si, KR;

Hyun Tae Jung, Pohang-si, KR;

Inventors:

Sei Kwang Hahn, Pohang-si, KR;

Jeong A. Yang, Pohang-si, KR;

Seung Kyu Yoon, Seocho-gu, KR;

Won Hee Hur, Seocho-gu, KR;

Ki Tae Park, Jeonju-si, KR;

Hye Min Kim, Pohang-si, KR;

Hyun Tae Jung, Pohang-si, KR;

Assignee:

POSTECH ACADEMY-INDUSTRY FOUNDATION, Pohang-si, Gyeongsangbuk-do, KR;

Attorney:

Panitch Schwarze Belisario & Nadel LLP

Primary Examiner:

Robert Landsman

Assistant Examiner:

Bruce D Hissong

Int. Cl.
CPC ...
C07K 14/56 (2006.01); C07K 14/565 (2006.01); C07K 14/57 (2006.01); C07K 14/525 (2006.01); C07K 17/10 (2006.01); A61K 38/21 (2006.01); A61K 47/48 (2006.01); A61K 31/726 (2006.01); A61K 31/728 (2006.01); A61K 47/36 (2006.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
C07K 14/56 (2013.01); A61K 31/726 (2013.01); A61K 31/728 (2013.01); A61K 38/191 (2013.01); A61K 38/21 (2013.01); A61K 38/212 (2013.01); A61K 38/215 (2013.01); A61K 38/217 (2013.01); A61K 47/36 (2013.01); A61K 47/4823 (2013.01); C07K 14/525 (2013.01); C07K 14/565 (2013.01); C07K 14/57 (2013.01); C07K 17/10 (2013.01);
Abstract

An HA-protein conjugate in which an HA-aldehyde derivative, in which an aldehyde group is introduced to a hyaluronic acid or a salt thereof, is conjugated to the N-terminus of a protein, and a method for preparing the same are provided. The HA-protein conjugate includes a protein drug exhibiting an excellent bioconjugation efficiency and long-term medicinal effects, and has excellent protein drug activities since the hyaluronic acid is specifically conjugated to the N-terminus of the protein. Also, since liver-targeting properties of the hyaluronic acid can be freely controlled by changing an aldehyde substitution rate of the HA-aldehyde derivative, the HA-protein conjugate can be effectively used as a protein drug for treating liver diseases, and also be useful in enabling long-term medicinal effects of a protein drug required to bypass the liver. Accordingly, the HA-protein conjugate can be effectively used for a drug delivery system of proteins.

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