The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
Mar. 20, 2013
Isis Pharmaceuticals, Inc., Carlsbad, CA;
Punit P. Seth, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Stephen Hanessian, Beaconsfield, CA;
Benjamin R. Schroeder, Green Brook, NJ (US);
Robert D. Giacometti, Montreal, CA;
Bradley L. Merner, Laval, CA;
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4′ ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.