The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
May. 17, 2012
Applicant:
Erik M. Schwiebert, Birmingham, AL (US);
Inventor:
Erik M. Schwiebert, Birmingham, AL (US);
Assignee:
DISCOVERYBIOMED INC., Birmingham, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 513/04 (2006.01); A61K 31/513 (2006.01); G01N 33/50 (2006.01); G01N 33/84 (2006.01); C07D 239/95 (2006.01); C07D 487/04 (2006.01); C07D 223/04 (2006.01); C07D 239/42 (2006.01); C07D 241/52 (2006.01); C07D 251/46 (2006.01); C07D 417/04 (2006.01); C07D 473/06 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); C07D 223/04 (2013.01); C07D 239/42 (2013.01); C07D 239/95 (2013.01); C07D 241/52 (2013.01); C07D 251/46 (2013.01); C07D 417/04 (2013.01); C07D 473/06 (2013.01); C07D 487/04 (2013.01); G01N 33/502 (2013.01); G01N 33/84 (2013.01); G01N 2800/382 (2013.01);
Abstract
Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.