The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 29, 2015

Filed:

Oct. 25, 2011
Applicants:

Zhijian LU, Clinton, NJ (US);

Yi-heng Chen, Whippany, NJ (US);

Cameron Smith, Lawrenceville, NJ (US);

Hong LI, Edison, NJ (US);

Christopher F. Thompson, Arlington, MA (US);

Julianne Hunt, Montclair, NJ (US);

Florida Kallashi, Lawrence Harbor, NJ (US);

Ramzi Sweis, Lake Bluff, IL (US);

Peter Sinclair, Doylestown, PA (US);

Samantha E. Adamson, Charlottesville, VA (US);

Guizhen Dong, Dayton, NJ (US);

Debra L. Ondeyka, Fanwood, NJ (US);

Xiaoxia Qian, New York, NY (US);

Wanying Sun, Edison, NJ (US);

Petr Vachal, Summit, NJ (US);

Kake Zhao, Westfield, NJ (US);

Inventors:

Zhijian Lu, Clinton, NJ (US);

Yi-Heng Chen, Whippany, NJ (US);

Cameron Smith, Lawrenceville, NJ (US);

Hong Li, Edison, NJ (US);

Christopher F. Thompson, Arlington, MA (US);

Julianne Hunt, Montclair, NJ (US);

Florida Kallashi, Lawrence Harbor, NJ (US);

Ramzi Sweis, Lake Bluff, IL (US);

Peter Sinclair, Doylestown, PA (US);

Samantha E. Adamson, Charlottesville, VA (US);

Guizhen Dong, Dayton, NJ (US);

Debra L. Ondeyka, Fanwood, NJ (US);

Xiaoxia Qian, New York, NY (US);

Wanying Sun, Edison, NJ (US);

Petr Vachal, Summit, NJ (US);

Kake Zhao, Westfield, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/4545 (2006.01); A61K 31/497 (2006.01); A61K 31/444 (2006.01); C07D 491/08 (2006.01); C07D 417/14 (2006.01); C07D 413/14 (2006.01); A61K 31/42 (2006.01); A61K 45/06 (2006.01); C07D 413/06 (2006.01);
U.S. Cl.
CPC ...
C07D 491/08 (2013.01); A61K 31/42 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, Ais a substituted phenyl group or indanyl group. Formula (I).


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