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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9221809 B1

PDFFull Text
Date of Patent:
Dec. 29, 2015

Filed:

Oct. 26, 2012

Aminopyrimidinones as interleukin receptor-associated kinase inhibitors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

W. Michael Seganish, Scotch Plains, NJ (US);

Stephanie Nicole Brumfield, Cranbury, NJ (US);

Jongwon Lim, Lexington, MA (US);

Julius J. Matasi, Monmouth Junction, NJ (US);

William T. McElroy, Plainfield, NJ (US);

Deen B. Tulshian, Lebanon, NJ (US);

Brian J. Lavey, New Providence, NJ (US);

Michael D. Altman, Needham, MA (US);

Craig R. Gibeau, Natick, MA (US);

John William Lampe, Norfolk, MA (US);

Joey Methot, Westwood, MA (US);

Liang Zhu, Belmont, MA (US);

Assignee:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

Attorneys:

Matthew A. Leff

John C. Todaro

Primary Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
A61K 31/515 (2006.01); C07D 417/04 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 491/08 (2006.01); C07D 401/04 (2006.01); C07D 417/14 (2006.01); C07D 453/02 (2006.01); C07D 471/08 (2006.01); C07D 487/10 (2006.01); C07D 491/10 (2006.01); C07D 495/08 (2006.01); C07D 513/04 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 417/04 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01); C07D 487/10 (2013.01); C07D 491/08 (2013.01); C07D 491/10 (2013.01); C07D 491/107 (2013.01); C07D 495/08 (2013.01); C07D 513/04 (2013.01);
Abstract

This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.

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