The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
Nov. 28, 2011
Nthato Chirwa, Johannesburg, ZA;
Viness Pillay, Johannesburg, ZA;
Yahya Essop Choonara, Johannesburg, ZA;
Pradeep Kumar, Johannesburg, ZA;
Lisa Claire Du Toit, Johannesburg, ZA;
Nthato Chirwa, Johannesburg, ZA;
Viness Pillay, Johannesburg, ZA;
Yahya Essop Choonara, Johannesburg, ZA;
Pradeep Kumar, Johannesburg, ZA;
Lisa Claire Du Toit, Johannesburg, ZA;
UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG, Johannesburg, ZA;
Abstract
A pharmaceutical composition for intraperitoneal delivery of an anti-neoplastic agent is provided for treating cancers associated with aberrant mucin expression, preferably ovarian cancer and pancreatic, prostate, metastatic breast, bladder and lung cancers. The composition comprises nanomicelles loaded with the anti-neoplastic agent, and antibodies such as anti-MUC16, anti-MUC1 or anti-MUC4 are conjugated to these nanomicelles. The antibody-bound nanomicelles are optionally embedded in a biodegradable pH- and thermo-responsive hydrogel capable of sol-gel transition at body temperature. The pharmaceutical composition is implantable in the peritoneum, where it transforms into a semi-solid gel at the body's core temperature. In response to pH, the hydrogel swells and releases the antibody-bound nanomicelles. The nanomicelles specifically target mucin antigens on cancer cells. The anti-mucin antibodies can be internalized by the tumor cells, enabling the drug-loaded nanomicelles to gain entry and deliver the chemotherapeutic drugs inside the tumor cell.