The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
May. 31, 2013
Ohio State Innovation Foundation, Columbus, OH (US);
Danilo Perrotti, Dublin, OH (US);
Paolo Neviani, Columbus, OH (US);
NATIONAL INSTITUTES OF HEALTH (NIH), Bethesda, MD (US);
U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), Bethesda, MD (US);
THE UNITED STATES OF AMERICA NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR), Washington, DC (US);
Abstract
A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula I: I wherein Ris independently selected from hydrogen and methyl; Ris selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: II wherein Ris a C-Calkyl or C-Calkoxy group; Ris independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and Ris an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof.