The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2015
Filed:
Mar. 20, 2009
Hanne Jørgensen, Trondheim, NO;
Trond Erling Ellingsen, Trondheim, NO;
Kristin Fløgstad Degnes, Trondheim, NO;
Per Bruheim, Trondheim, NO;
Håvard Sletta, Trondheim, NO;
Espen Fjærvik, Trondheim, NO;
Geir Klinkenberg, Heimdal, NO;
Sergey Zotchev, Trondheim, NO;
Hanne Jørgensen, Trondheim, NO;
Trond Erling Ellingsen, Trondheim, NO;
Kristin Fløgstad Degnes, Trondheim, NO;
Per Bruheim, Trondheim, NO;
Håvard Sletta, Trondheim, NO;
Espen Fjærvik, Trondheim, NO;
Geir Klinkenberg, Heimdal, NO;
Sergey Zotchev, Trondheim, NO;
SINTEF TTO AS, Trondheim, NO;
Abstract
The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said microorganism.