The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2015

Filed:

Jul. 27, 2011
Applicants:

Josue Alfaro-lopez, San Diego, CA (US);

Abhinandini Sharma, San Diego, CA (US);

Christopher J. Soares, Wilmington, DE (US);

Eugene Coats, Wilmington, DE (US);

Soumitra S. Ghosh, Wilmington, DE (US);

Inventors:

Josue Alfaro-Lopez, San Diego, CA (US);

Abhinandini Sharma, San Diego, CA (US);

Christopher J. Soares, Wilmington, DE (US);

Eugene Coats, Wilmington, DE (US);

Soumitra S. Ghosh, Wilmington, DE (US);

Assignees:

AstraZeneca Pharmaceuticals LP, Wilmington, DE (US);

Amylin Pharmaceuticals, LLC, Wilmington, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/605 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); A61K 38/00 (2013.01); Y02E 50/343 (2013.01);
Abstract

The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4.


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