The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2015
Filed:
Apr. 08, 2010
Applicants:
Zhong-yin Zhang, Carmel, IN (US);
Sheng Zhang, Carmel, IN (US);
Inventors:
Zhong-Yin Zhang, Carmel, IN (US);
Sheng Zhang, Carmel, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 9/00 (2006.01); C07K 5/065 (2006.01); C07K 5/087 (2006.01); C12Q 1/42 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06078 (2013.01); C07K 5/0812 (2013.01); C12Q 1/42 (2013.01); G01N 33/505 (2013.01); A61K 38/00 (2013.01); G01N 2333/916 (2013.01);
Abstract
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.