The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2015

Filed:

Jul. 24, 2014
Applicants:

Purdue Research Foundation, West Lafayette, IN (US);

The United States of America As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

Inventors:

Mark S. Cushman, West Lafayette, IN (US);

Andrew E. Morrell, San Diego, CA (US);

Muthukaman Nagarajan, Hyderabad, IN;

Yves G. Pommier, Bethesda, MD (US);

Keli K. Agama, Germantown, MD (US);

Smitha Antony, Silver Springs, MD (US);

Daniel E. Beck, Lafayette, IN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/18 (2006.01); C07J 73/00 (2006.01); A61K 31/473 (2006.01); A61K 31/4741 (2006.01);
U.S. Cl.
CPC ...
C07J 73/005 (2013.01); A61K 31/473 (2013.01); A61K 31/4741 (2013.01); C07D 221/18 (2013.01); C07J 73/003 (2013.01);
Abstract

N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.


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