The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2015
Filed:
Jul. 09, 2013
Dai Cheng, San Diego, CA (US);
Dong Han, San Diego, CA (US);
Guobao Zhang, San Diego, CA (US);
Yongqin Wan, Irvine, CA (US);
Yun Feng Xie, San Diego, CA (US);
Jiqing Jiang, San Diego, CA (US);
Wenqi Gao, San Diego, CA (US);
Shifeng Pan, San Diego, CA (US);
Dai Cheng, San Diego, CA (US);
Dong Han, San Diego, CA (US);
Guobao Zhang, San Diego, CA (US);
Yongqin Wan, Irvine, CA (US);
Yun Feng Xie, San Diego, CA (US);
Jiqing Jiang, San Diego, CA (US);
Wenqi Gao, San Diego, CA (US);
Shifeng Pan, San Diego, CA (US);
Novartis AG, Basel, CH;
Abstract
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).