The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2015
Filed:
Dec. 23, 2014
Applicant:
Lipoxen Technologies Limited, London, GB;
Inventors:
Assignee:
Lipoxen Technologies Limited, , GB;
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/26 (2006.01); A61K 47/48 (2006.01); C08B 37/00 (2006.01); C08H 1/02 (2006.01); C07H 5/06 (2006.01); C07K 17/10 (2006.01); C12N 9/96 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); C07H 5/06 (2013.01); C07H 15/26 (2013.01); C07K 17/10 (2013.01); C08B 37/0006 (2013.01); C08H 1/02 (2013.01); C12N 9/96 (2013.01);
Abstract
Derivatives of PSAs are synthesized, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.