The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2015
Filed:
Aug. 23, 2011
Masamichi Hashimoto, Machida, JP;
Tadashi Morikawa, Chuo-ku, JP;
Yoshiaki Miyata, Chuo-ku, JP;
Akio Ohno, Machida, JP;
Kei Takahashi, Machida, JP;
Daisuke Ogasawara, Machida, JP;
Kenji Fujii, Machida, JP;
Teruaki Kakema, Machida, JP;
Mariko Takeda, Machida, JP;
Masamichi Hashimoto, Machida, JP;
Tadashi Morikawa, Chuo-ku, JP;
Yoshiaki Miyata, Chuo-ku, JP;
Akio Ohno, Machida, JP;
Kei Takahashi, Machida, JP;
Daisuke Ogasawara, Machida, JP;
Kenji Fujii, Machida, JP;
Teruaki Kakema, Machida, JP;
Mariko Takeda, Machida, JP;
DENKI KAGAKU KOGYO KABUSHIKI KAISHA, Tokyo, JP;
Abstract
The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %. The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.