The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 15, 2015

Filed:

Oct. 01, 2013
Applicants:

The Regents of the University of Colorado, a Body Corporate, Denver, CO (US);

Musc Foundation for Research Development, Charleston, SC (US);

Inventors:

Gary Gilkeson, Charleston, SC (US);

Stephen Tomlinson, Mount Pleasant, SC (US);

V. Michael Holers, Denver, CO (US);

Baerbel Rohrer, Mount Pleasant, SC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); C07K 14/47 (2013.01); C07K 14/70596 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.


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