The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2015
Filed:
Dec. 22, 2008
Wenche Stensen, Kvaloysletta, NO;
Oystein Rekdal, Hvalstad, NO;
John Sigurd Svendsen, Kvaloysletta, NO;
Wenche Stensen, Kvaloysletta, NO;
Oystein Rekdal, Hvalstad, NO;
John Sigurd Svendsen, Kvaloysletta, NO;
Lytix Biopharma AS, Tromsø, NO;
Abstract
The present invention relates to a method of improving the resistance of a peptide or peptidomimetic to degradation by trypsin which comprises incorporating into said peptide or peptidomimetic a C-terminal capping group of formula (I): X—Y—Z (I) wherein X is a N atom, which may be substituted by a branched or unbranched C-Calkyl or aryl group which group may incorporate up to 2 heteroatoms selected from N, O and S; Y represents a group selected from —R—R—, —R—R—R,- and —R—R—R— wherein Ris C, O, S or N, and Ris C; each of Rand R, may be substituted by C-Calkyl groups or unsubstituted; and Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogen atoms, 2 or more of the cyclic groups may be fused and one or more of the cyclic groups may be substituted; the Z. moiety incorporates a maximum of 15 non-hydrogen atoms; and wherein the bond between Y and Z is a covalent bond between Ror Rof Y and a non-hydrogen atom of one of the cyclic groups of Z.