The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 15, 2015

Filed:

May. 16, 2012
Applicants:

Francine Acher, Vaucresson, FR;

Jean-philippe Pin, Montpellier, FR;

Cyril Goudet, Saint Gely du Fesc, FR;

Alain Eschalier, Chamalières, FR;

Jérôme Busserolles, Saulzet, FR;

Delphine Rigault, Viroflay, FR;

Isabelle Lemasson, Paris, FR;

Sara Cesarini, Paris, IT;

Bruno Commare, Les Ventes Saint-Rémy, FR;

Inventors:

Francine Acher, Vaucresson, FR;

Jean-Philippe Pin, Montpellier, FR;

Cyril Goudet, Saint Gely du Fesc, FR;

Alain Eschalier, Chamalières, FR;

Jérôme Busserolles, Saulzet, FR;

Delphine Rigault, Viroflay, FR;

Isabelle Lemasson, Paris, FR;

Sara Cesarini, Paris, IT;

Bruno Commare, Les Ventes Saint-Rémy, FR;

Assignees:

UNIVERSITE PARIS DESCARTES, Paris, FR;

UNIVERSITE D'AUVERGNE, Clermont-Ferrand, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 9/30 (2006.01); A61K 31/662 (2006.01); A61P 25/00 (2006.01); C07F 9/38 (2006.01); C07F 9/48 (2006.01);
U.S. Cl.
CPC ...
C07F 9/3834 (2013.01); C07F 9/301 (2013.01); C07F 9/306 (2013.01); C07F 9/3808 (2013.01); C07F 9/4816 (2013.01);
Abstract

The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R-R, identical or different, two of R-Roptionally occupying the same position on the phenyl group, one to four of R-Rbeing H and the others being selected in the group comprising -0-(CH)—COOH; —S—(CH)—COOH; —NH—(CH)—COOH; -0-(CH,R')—COOH; —O—(CH)—OH; OR′, —R′ being a C-Calkyl radical; —OH; —COOH; halogen, particularly —F, —CI, —Br, —I, —CF; —OCF; —N0; —CH═CH—COOH; —(CH)—COOH; O—(CH)—P0H; O—(CF)—P0H; O—(CH)—S0H; O—(CH)—CONHOH; O—(CH)-tetrazol; O—(CH)-hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.


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