The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2015
Filed:
Sep. 12, 2012
Applicants:
Hermann Steller, New York, NY (US);
Cristinel Sandu, New York, NY (US);
Anshuman Kelkar, New York, NY (US);
Nidhi Gangadhar, New York, NY (US);
Inventors:
Hermann Steller, New York, NY (US);
Cristinel Sandu, New York, NY (US);
Anshuman Kelkar, New York, NY (US);
Nidhi Gangadhar, New York, NY (US);
Assignee:
The Rockefeller University, New York, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 55/02 (2006.01); A61K 31/555 (2006.01); C07D 401/14 (2006.01); C07D 303/46 (2006.01); C07D 303/40 (2006.01); C07D 413/14 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 303/40 (2013.01); C07D 303/46 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract
Pro-apoptotic compounds having a tripartite structure:A-L-Bare disclosed. In these compounds A is an IBM mimetic moiety; L is a linker and B is a moiety that binds to a protein on the outer mitochondrial membrane. The compounds are useful for inducing cell apoptosis and therefore treating cancer. An example of such a compound is