The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 15, 2015

Filed:

Aug. 29, 2013
Applicant:

Ablynx N.v., Zwijnaarde, BE;

Inventors:

John E. Park, Warthausen, DE;

Cornelia Dorner-Ciossek, Warthausen, DE;

Stefan Hoerer, Biberach an der Riss, DE;

Lothar Kussmaul, Schemmerhofen, DE;

Martin Lenter, Neu-Ulm, DE;

Katharina Zimmerman, Biberach an der Riss, DE;

Gerald Beste, Ghent, BE;

Toon Laeremans, Dworp-Beersel, BE;

Pascal Gerard Merchiers, Tielen, BE;

Jo Vercammen, Sint-Pieters-Leeuw, BE;

Assignee:

Ablynx N.V., Zwijnaarde, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/40 (2013.01); C07K 2317/55 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01);
Abstract

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.


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