The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2015
Filed:
Nov. 08, 2010
Klaus Langer, Münster, DE;
Matthias Wacker, Nidderau, DE;
Beate Röder, Falkensee, DE;
Annegret Preuss, Berlin, DE;
Volker Albrecht, Bergholz Rehbrücke, DE;
Susanna Gräfe, Jena, DE;
Arno Wiehe, Berlin, DE;
Hagen Von Briesen, Hunstetten, DE;
Karin Löw, Saarlouis, DE;
Sylvia Wagner, Neunkirchen, DE;
Klaus Langer, Münster, DE;
Matthias Wacker, Nidderau, DE;
Beate Röder, Falkensee, DE;
Annegret Preuss, Berlin, DE;
Volker Albrecht, Bergholz Rehbrücke, DE;
Susanna Gräfe, Jena, DE;
Arno Wiehe, Berlin, DE;
Hagen von Briesen, Hunstetten, DE;
Karin Löw, Saarlouis, DE;
Sylvia Wagner, Neunkirchen, DE;
Biolitec Pharma Marketing Ltd, Labuan, MY;
Abstract
Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.