The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Dec. 03, 2009
Applicants:
Xiaoxia Cui, St. Louis, MO (US);
Aron M. Geurts, New Berlin, WI (US);
Fyodor Urnov, Point Richmond, CA (US);
Inventors:
Xiaoxia Cui, St. Louis, MO (US);
Aron M. Geurts, New Berlin, WI (US);
Fyodor Urnov, Point Richmond, CA (US);
Assignees:
Sangamo BioSciences, Inc., Richmond, CA (US);
Sigma-Aldrich Co. LLC, St. Louis, MO (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 9/22 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); A01K 67/0278 (2013.01); C12N 15/8509 (2013.01); A01K 2217/054 (2013.01); A01K 2217/15 (2013.01); A01K 2227/10 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0393 (2013.01); C07K 2319/00 (2013.01); C07K 2319/81 (2013.01); C12N 2800/80 (2013.01);
Abstract
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.