The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Nov. 10, 2011
Kalet León Monzón, Havana, CU;
Tania Carmenate Portilla, Havana, CU;
Saumel Pérez Rodriguez, Artemisa, CU;
Neris Michel Enamorado Escalona, Havana, CU;
Agustin Bienvenido Lage Dávila, Havana, CU;
Kalet León Monzón, Havana, CU;
Tania Carmenate Portilla, Havana, CU;
Saumel Pérez Rodriguez, Artemisa, CU;
Neris Michel Enamorado Escalona, Havana, CU;
Agustin Bienvenido Lage Dávila, Havana, CU;
CENTRO DE IMMUNOLOGIA MOLECULAR, Havana, CU;
Abstract
The present invention relates to polypeptides which share primary sequence with human IL-2, except for several amino acids that have been mutated. The mutations introduced substantially reduce the ability of these polypeptides to stimulate in vitro and in vivo regulatory T cells (T CD4+CD25+FoxP3+) and make them more effective in the therapy of murine transplantable tumors. Also includes therapeutic uses of these mutated variants, used alone or in combination with vaccines for the therapy of diseases such as cancer or infections where the activity of regulatory T cells (Tregs) is relevant. In another aspect the present invention relates to pharmaceutical compositions comprising as active principle the polypeptides disclosed. Finally, the present invention relates to the therapeutic use of the polypeptides and pharmaceutical compositions disclosed due to their modulating effect of the immune system on diseases like cancer and chronic infectious diseases.