The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
May. 02, 2013
Katerina Heran Darwin, New York, NY (US);
Nicolaas Sebastiaan Merkx, Amsterdam, NL;
Huib Ovaa, Amsterdam, NL;
Katerina Heran Darwin, New York, NY (US);
Nicolaas Sebastiaan Merkx, Amsterdam, NL;
Huib Ovaa, Amsterdam, NL;
New York University, New York, NY (US);
Abstract
Methods for making and using substrates of deamidase of prokaryotic ubiquitin-like protein (Dop) are described herein. More particularly, modified prokaryotic ubiquitin-like protein (Pup) and functional fragments thereof that serve as exemplary Dop substrates are described and encompassed herein. Screening methods to identify modulators of Dop and Pup activity and use of modulators identified thereby are also described. Methods of using modulators that are identified as inhibitors of Dop and Pup activity for treating diseases/conditions associated with(Mtb) infection, such as tuberculosis and leprosy, are also envisioned.