The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2015

Filed:

Mar. 18, 2013
Applicant:

Council of Scientific & Industrial Research, New Delhi, IN;

Inventors:

Ram Asrey Vishwakarma, Jammu, IN;

Sanghapal Damodhar Sawant, Jammu, IN;

Parvinder Pal Singh, Jammu, IN;

Abid Hamid Dar, Jammu, IN;

Parduman Raj Sharma, Jammu, IN;

Ajit Kumar Saxena, Jammu, IN;

Amit Nargotra, Jammu, IN;

Anjaneya Aravind Kumar Kolluru, Jammu, IN;

Ramesh Mudududdla, Jammu, IN;

Asif Khurshid Qazi, Jammu, IN;

Aashiq Hussain, Jammu, IN;

Nayan Chanauria, Jammu, IN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 5/02 (2006.01); A61K 31/69 (2006.01);
U.S. Cl.
CPC ...
C07F 5/025 (2013.01); A61K 31/69 (2013.01);
Abstract

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.


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