The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Dec. 11, 2012
Barbara Pio, West Orange, NJ (US);
Alexander Pasternak, Princeton, NJ (US);
Aurash Shahripour, Rahway, NJ (US);
Haifeng Tang, Metuchen, NJ (US);
Shawn Walsh, Bridgewater, NJ (US);
Barbara Pio, West Orange, NJ (US);
Alexander Pasternak, Princeton, NJ (US);
Aurash Shahripour, Rahway, NJ (US);
Haifeng Tang, Metuchen, NJ (US);
Shawn Walsh, Bridgewater, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.