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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9206186 B1

PDFFull Text
Date of Patent:
Dec. 08, 2015

Filed:

Aug. 26, 2013

2-phenoxy- and 2-phenylsulfonamide derivatives with ccr3 antagonistic activity for the treatment of inflammatory or immunological disorders

Applicant:

Axikin Pharmaceuticals, Inc., San Diego, CA (US);

Inventors:

Yingfu Li, Hamden, CT (US);

Kevin Bacon, San Diego, CA (US);

Hiromi Sugimoto, Kyoto, JP;

Keiko Fukushima, Nara-ken, JP;

Kentaro Hashimoto, Wuppertal, DE;

Makiko Marumo, Nara-ken, JP;

Toshiya Moriwaki, Nara-ken, JP;

Noriko Nunami, Hyogo-ken, JP;

Naoki Tsuno, Nara-ken, JP;

Klaus Urbahns, Lund, SE;

Nagahiro Yoshida, Kyoto, JP;

Assignee:

AXIKIN PHARMACEUTICALS, INC., San Diego, CA (US);

Attorney:

Jones Day

Primary Examiner:

Kara R McMillian

Int. Cl.
CPC ...
C07D 453/02 (2006.01); C07D 487/02 (2006.01); C07D 487/08 (2006.01); A61K 31/439 (2006.01); C07D 487/04 (2006.01); C07C 311/29 (2006.01); C07D 207/12 (2006.01); C07D 207/14 (2006.01); C07D 207/16 (2006.01); C07D 207/40 (2006.01); C07D 207/404 (2006.01); C07D 207/48 (2006.01); C07D 211/54 (2006.01); C07D 223/12 (2006.01); C07D 241/04 (2006.01); C07D 243/08 (2006.01); C07D 257/04 (2006.01); C07D 295/13 (2006.01); C07D 295/22 (2006.01); C07D 295/26 (2006.01); C07D 303/06 (2006.01); C07D 303/36 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/439 (2013.01); C07C 311/29 (2013.01); C07D 207/12 (2013.01); C07D 207/14 (2013.01); C07D 207/16 (2013.01); C07D 207/40 (2013.01); C07D 207/404 (2013.01); C07D 207/48 (2013.01); C07D 211/54 (2013.01); C07D 223/12 (2013.01); C07D 241/04 (2013.01); C07D 243/08 (2013.01); C07D 257/04 (2013.01); C07D 295/13 (2013.01); C07D 295/22 (2013.01); C07D 295/26 (2013.01); C07D 303/06 (2013.01); C07D 303/36 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 453/02 (2013.01); C07D 487/02 (2013.01); C07D 487/08 (2013.01);
Abstract

Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.

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