The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Jan. 12, 2012
Dinesh Kumar Dikshit, Lucknow, IN;
Madhu Dikshit, Lucknow, IN;
Tanveer Irshad Siddiqui, Lucknow, IN;
Anil Kumar, Lucknow, IN;
Rabi Sankar Bhatta, Lucknow, IN;
Girish Kumar Jain, Lucknow, IN;
Manoj Kumar Barthwal, Lucknow, IN;
Ankita Misra, Lucknow, IN;
Vivek Khanna, Lucknow, IN;
Prem Prakash, Lucknow, IN;
Manish Jain, Lucknow, IN;
Vishal Singh, Lucknow, IN;
Varsha Gupta, Lucknow, IN;
Anil Kumar Dwivedi, Lucknow, IN;
Dinesh Kumar Dikshit, Lucknow, IN;
Madhu Dikshit, Lucknow, IN;
Tanveer Irshad Siddiqui, Lucknow, IN;
Anil Kumar, Lucknow, IN;
Rabi Sankar Bhatta, Lucknow, IN;
Girish Kumar Jain, Lucknow, IN;
Manoj Kumar Barthwal, Lucknow, IN;
Ankita Misra, Lucknow, IN;
Vivek Khanna, Lucknow, IN;
Prem Prakash, Lucknow, IN;
Manish Jain, Lucknow, IN;
Vishal Singh, Lucknow, IN;
Varsha Gupta, Lucknow, IN;
Anil Kumar Dwivedi, Lucknow, IN;
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, New Delhi, IN;
Abstract
Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)—{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)—{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.