The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9206133 B1

PDF
Full Text
Expired
Date of Patent:
Dec. 08, 2015

Filed:

Jun. 05, 2012
Applicants:

Walter Cabri, Rozzano, IT;

Roberto Castagnani, Sezze Scalo, IT;

Silvia Armaroli, Gallo Poggio Renatico, IT;

Gianandrea Quattrociocchi, Veroli, IT;

Vincenzo Colangeli, Pomezia, IT;

Inventors:

Walter Cabri, Rozzano, IT;

Roberto Castagnani, Sezze Scalo, IT;

Silvia Armaroli, Gallo Poggio Renatico, IT;

Gianandrea Quattrociocchi, Veroli, IT;

Vincenzo Colangeli, Pomezia, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 215/46 (2006.01);
U.S. Cl.
CPC ...
C07D 215/46 (2013.01);
Abstract

The present invention provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts.


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