The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Jun. 22, 2012
Applicants:
Paul Chapman, New York, NY (US);
Lisa Davidson, Edingburgh, GB;
José W. Saldanha, Middlesex, GB;
Inventors:
Assignee:
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 51/10 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 51/1066 (2013.01); A61K 39/00 (2013.01); A61K 39/39558 (2013.01); C07K 16/3084 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention is related to complementarity determining region (CDR)-grafted humanized R24 antibodies that bind to the GD3 ganglioside antigen. The humanized antibodies disclosed herein have characteristics that are comparable or superior to the murine R24 antibody, and the humanized antibodies are useful in treating cancer (e.g. Melanoma).