The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Dec. 04, 2014
Applicant:
The University of British Columbia, Vancouver, CA;
Inventors:
Martin E. Gleave, Vancouver, CA;
Joseph Ischia, Victoria, AU;
Assignee:
The University of British Columbia, Vancouver, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07H 21/04 (2006.01); C07H 21/02 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); A61K 31/4166 (2006.01); A61K 31/712 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 31/4166 (2013.01); A61K 31/712 (2013.01); A61K 45/06 (2013.01);
Abstract
Castrate resistant prostate cancer cell lines exhibiting resistance to the androgen-receptor antagonist enzaluatamide overexpress one or both of IGFBP-2 or IGFBP-5 when compared to non-resistant cell lines. Oligonucleotides that target IGFBP-2 and IGFBP-5 can be used to overcome this resistance or as part of a treatment program when administered concurrently with the administration of androgen-receptor antagonist treatments.