The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Mar. 01, 2012
Andrew E. Gelman, Saint Louis, MO (US);
Elena Feinstein, Rehovot, IL;
Svetlana Adamsky, Gedera, IL;
Igor Mett, Rehovot, IL;
Hagar Kalinski, Rishon-le-Zion, IL;
Sharon Avkin-nachum, Nes Zionna, IL;
Andrew E. Gelman, Saint Louis, MO (US);
Elena Feinstein, Rehovot, IL;
Svetlana Adamsky, Gedera, IL;
Igor Mett, Rehovot, IL;
Hagar Kalinski, Rishon-le-Zion, IL;
Sharon Avkin-Nachum, Nes Zionna, IL;
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Washington University, Saint Louis, MO (US);
Abstract
Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.