The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Oct. 06, 2010
Applicant:
Andrei V. Gudkov, East Aurora, NY (US);
Inventor:
Andrei V. Gudkov, East Aurora, NY (US);
Assignee:
Panacela Labs, LLC, Moscow, RU;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 31/59 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01); A61K 38/27 (2006.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); C12N 15/85 (2006.01); C12N 15/63 (2006.01); C12N 15/79 (2006.01); A61K 39/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 31/59 (2013.01); A61K 38/164 (2013.01); A61K 38/177 (2013.01); A61K 38/18 (2013.01); A61K 38/2257 (2013.01); A61K 38/27 (2013.01); A61K 48/005 (2013.01); C07K 14/705 (2013.01); A61K 39/0011 (2013.01); C12N 15/63 (2013.01); C12N 15/79 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); C12N 2799/021 (2013.01); C12N 2830/20 (2013.01);
Abstract
The present invention is directed to methods and agents used for treating cancer or infectious diseases by providing toll-like receptors such as toll-like receptor 5 (TLR-5) in combination with providing a toll-like receptor agonists such as flagellin resulting in a cis and in-trans effect that recruits cells involved in both the innate (cis effect) and adaptive (trans effect) immune response to specifically kill cancer cells and cells infected with a pathogen via the NF-κB apoptosis pathway.