The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
Nov. 12, 2010
Anna E. Maciag, Frederick, MD (US);
Larry K. Keefer, Bethesda, MD (US);
Joseph E. Saavedra, Thurmont, MD (US);
Lucy M. Anderson, Catonsville, MD (US);
Harinath Chakrapani, Pashan Pune, IN;
Anna E. Maciag, Frederick, MD (US);
Larry K. Keefer, Bethesda, MD (US);
Joseph E. Saavedra, Thurmont, MD (US);
Lucy M. Anderson, Catonsville, MD (US);
Harinath Chakrapani, Pashan Pune, IN;
Abstract
Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (NO-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.