The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Feb. 06, 2007
Huafang Gao, Beijing, CN;
Ze LI, Beijing, CN;
Dong Wang, Beijing, CN;
Yanhua Liu, Beijing, CN;
Xiang Liu, Beijing, CN;
Yangzhou Jiang, Beijing, CN;
LI LI, Beijing, CN;
Chuanzan Zhao, Beijing, CN;
Gengxin Lan, Beijing, CN;
Tao Guo, Beijing, CN;
Bin Cai, Beijing, CN;
Jing Cheng, Beijing, CN;
Huafang Gao, Beijing, CN;
Ze Li, Beijing, CN;
Dong Wang, Beijing, CN;
Yanhua Liu, Beijing, CN;
Xiang Liu, Beijing, CN;
Yangzhou Jiang, Beijing, CN;
Li Li, Beijing, CN;
Chuanzan Zhao, Beijing, CN;
Gengxin Lan, Beijing, CN;
Tao Guo, Beijing, CN;
Bin Cai, Beijing, CN;
Jing Cheng, Beijing, CN;
CapitalBio Corporation, Beijing, CN;
Tsinghua University, Beijing, CN;
Abstract
The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.