The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Oct. 29, 2014
Applicant:
Vascular Biogenics Ltd., Or Yehuda, IL;
Inventors:
Eyal Breitbart, Hashmonaim, IL;
Andrea Leubitz, Efrat, IL;
Erez Feige, Hemed, IL;
Richard Penson, Braintree, MA (US);
Assignee:
Vascular Biogenics Ltd., Or Yehuda, IL;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); A01N 63/00 (2006.01); C12N 15/00 (2006.01); C07K 14/705 (2006.01); A61K 35/761 (2015.01); A61K 48/00 (2006.01); A61K 31/337 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70503 (2013.01); A61K 31/337 (2013.01); A61K 31/713 (2013.01); A61K 35/761 (2013.01); A61K 45/06 (2013.01); A61K 48/00 (2013.01); C12N 7/00 (2013.01); C12N 2710/10043 (2013.01);
Abstract
The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor or inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient by administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter. Also provided is a homogeneous population of an adenovirus comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and its uses thereof.