The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Feb. 09, 2015
Korea Research Institute of Chemical Technology, Daejeon, KR;
Kwangho Lee, Daejeon, KR;
Hyoung Rae Kim, Daejeon, KR;
Chi Hoon Park, Daejeon, KR;
Chong Ock Lee, Seoul, KR;
Jong Kook Lee, Chuncheon-si, KR;
Hee Jung Jung, Daejeon, KR;
Sung Yun Cho, Daejeon, KR;
Chong Hak Chae, Daejeon, KR;
Sang Un Choi, Daejeon, KR;
Jae Du Ha, Daejeon, KR;
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, Daejeon-si, KR;
Abstract
Disclosed herein are a new N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancers containing the same as an active ingredient. The compound of the present invention has excellent inhibitory effects against the activities of anaplastic lymphoma kinase (ALK) and activated cdc42-associated kinase (ACK1) and thus can improve the therapeutic effects on the treatment of cancer cells having anaplastic lymphoma kinase fusion proteins such as EML4-ALK and NPM-ALK, and also effectively prevent the recurrence of cancers thus being useful as a pharmaceutical composition for the prevention and treatment of cancers.