The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Nov. 01, 2012
Hoffmann-la Roche Inc., Nutley, NJ (US);
Simona M. Ceccarelli, Basel, CH;
Aurelia Conte, Shanghai, CN;
Holger Kuehne, Loerrach, DE;
Bernd Kuhn, Reinach BL, CH;
Werner Neidhart, Hagenthal-le-Bas, FR;
Ulrike Obst Sander, Reinach BL, CH;
Markus Rudolph, Basel, CH;
HOFFMANN-LA ROCHE INC., Nutley, NJ (US);
Abstract
The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, Rand n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.