The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Oct. 27, 2011
Beth-ann Griswold Coller, Kaneohe, HI (US);
Vidya B. Pai, Rockville, MD (US);
D. Elliot Parks, Del Mar, CA (US);
Michele Yelmene, Del Mar, CA (US);
Andrew J. Bett, Lansdale, PA (US);
Timothy Martyak, Aiea, HI (US);
Beth-Ann Griswold Coller, Kaneohe, HI (US);
Vidya B. Pai, Rockville, MD (US);
D. Elliot Parks, Del Mar, CA (US);
Michele Yelmene, Del Mar, CA (US);
Andrew J. Bett, Lansdale, PA (US);
Timothy Martyak, Aiea, HI (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients.