The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Sep. 22, 2009
Luis M. Alvarez, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Richard T. Lee, Weston, MA (US);
Luis M. Alvarez, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Richard T. Lee, Weston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific receptor pairs can be used to control (e.g., promote or inhibit) signaling, and, therefore, the ligand dimers provided can also be used in various forms of treatment in which such signaling control is beneficial to a subject. It follows that methods for controlling signaling are provided as are various methods of treatment.