The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Nov. 22, 2011
Applicant:
Melha Mellata, Scottsdale, AZ (US);
Inventor:
Melha Mellata, Scottsdale, AZ (US);
Assignee:
Arizona Board of Regents on behalf of Arizona State University, Tempe, AZ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/112 (2006.01); A61K 39/02 (2006.01); A61K 49/00 (2006.01); A61K 38/16 (2006.01); C12N 1/38 (2006.01); C12N 15/74 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/164 (2013.01); A61K 39/0275 (2013.01); C12N 1/38 (2013.01); C12N 15/74 (2013.01); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); A61K 2039/585 (2013.01);
Abstract
The present invention encompasses recombinant bacteria suitable for live attenuated vaccines, and methods of use thereof. One aspect of the present invention encompasses a recombinantbacterium. The bacterium comprises a first promoter operably linked to a nucleic acid encoding a toxin and a second promoter operably linked to a nucleic acid encoding an antitoxin, wherein the second promoter is inactive in vivo, but active in vitro.