The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2015
Filed:
Apr. 20, 2012
David V. Schaffer, Danville, CA (US);
Ryan R. Klimczak, San Francisco, CA (US);
James T. Koerber, San Francisco, CA (US);
John G. Flannery, Berkeley, CA (US);
Deniz Dalkara Mourot, Berkeley, CA (US);
Meike Visel, El Cerrito, CA (US);
Leah C. T. Byrne, Berkeley, CA (US);
David V. Schaffer, Danville, CA (US);
Ryan R. Klimczak, San Francisco, CA (US);
James T. Koerber, San Francisco, CA (US);
John G. Flannery, Berkeley, CA (US);
Deniz Dalkara Mourot, Berkeley, CA (US);
Meike Visel, El Cerrito, CA (US);
Leah C. T. Byrne, Berkeley, CA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Abstract
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.