The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2015
Filed:
Apr. 02, 2012
Applicants:
Michael Hoffman, Rochester, NY (US);
Danielle Benoit, Rochester, NY (US);
Inventors:
Michael Hoffman, Rochester, NY (US);
Danielle Benoit, Rochester, NY (US);
Assignee:
University of Rochester, Rochester, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/00 (2006.01); C12N 5/0775 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0662 (2013.01); C12N 5/0012 (2013.01); C12N 5/0663 (2013.01); C12N 2501/727 (2013.01);
Abstract
Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3'-oxime (BIO). This results in robust proliferation and 'stemness' in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.