The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2015
Filed:
Sep. 06, 2012
Anthony Coyle, Boston, MA (US);
Yihong Yao, Boyds, MD (US);
Bahija Jallal, Potomac, MD (US);
Gianluca Carlesso, Rockville, MD (US);
Michael Bowen, Rockville, MD (US);
Anthony Coyle, Boston, MA (US);
Yihong Yao, Boyds, MD (US);
Bahija Jallal, Potomac, MD (US);
Gianluca Carlesso, Rockville, MD (US);
Michael Bowen, Rockville, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonization) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder.