The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
Dec. 01, 2005
Marie Lacombe, Charenton-le-Pont, FR;
Franciscus Johannes Opdam, Alkmaar, NL;
Eduard Gerhard Talman, Diemen, NL;
Jacky Theo Maria Veuskens, Hasselt, BE;
Marie Lacombe, Charenton-le-Pont, FR;
Franciscus Johannes Opdam, Alkmaar, NL;
Eduard Gerhard Talman, Diemen, NL;
Jacky Theo Maria Veuskens, Hasselt, BE;
LEICA BIOSYSTEMS NEWCASTLE LTD., Newcastle Upon Tyne, GB;
Abstract
The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities. In addition, the present invention also relates to a set of at least two of said transition metal complexes of different molecular mass, to transition metal complexes comprising different stable isotopes, to chemical or biological entities obtained by a method of the invention and to a kit of parts supporting the use and/or methods of the invention.