The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

Sep. 27, 2012
Applicants:

University College Cork National University of Ireland, Cork, IE;

University of Kent, Canterbury Kent, GB;

Inventors:

Michael Prentice, Cork, IE;

Martin Warren, Canterbury Kent, IE;

Mingzhi Liang, Cork, IE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/19 (2006.01); C12Q 1/02 (2006.01); C12P 3/00 (2006.01); A23L 1/30 (2006.01); C07K 14/195 (2006.01); C12N 1/20 (2006.01); C12N 9/12 (2006.01); C12N 15/70 (2006.01); C12P 21/00 (2006.01); A61K 38/45 (2006.01);
U.S. Cl.
CPC ...
C12P 3/00 (2013.01); A23L 1/3014 (2013.01); C07K 14/195 (2013.01); C12N 1/20 (2013.01); C12N 9/1229 (2013.01); C12N 15/70 (2013.01); C12P 21/00 (2013.01); C12Y 207/04001 (2013.01); A61K 38/45 (2013.01);
Abstract

A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is transformed to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolized to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.


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