The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

Apr. 29, 2014
Applicant:

Ajinomoto Co., Inc., Tokyo, JP;

Inventors:

Yoshihiko Matsuda, Kanagawa, JP;

Hiroshi Itaya, Kanagawa, JP;

Yoshimi Kikuchi, Kanagawa, JP;

Haruki Beppu, Kanagawa, JP;

Jurgis Antanas Vladovich Jomantas, Moscow, RU;

Ekaterina Aleksandrovna Kutukova, Moscow, RU;

Assignee:

AJINOMOTO CO., INC., Tokyo, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/34 (2006.01); C12N 15/77 (2006.01); C07K 14/34 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C07K 14/34 (2013.01); C12N 15/77 (2013.01);
Abstract

A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production.


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